Cross-Talk between Bone Morphogenic Proteins and Estrogen Receptor Signaling
نویسندگان
چکیده
منابع مشابه
Title: Cross-talk between Bone Morphogenic Proteins and Estrogen Receptor Signaling Abbreviated title: Cross-talk between BMPs and ER
Bone morphogenic proteins (BMPs) play central roles in differentiation, development, and physiologic tissue remodeling. Estrogens have key roles in variety of biological events, such as the development and maintenance of numerous target tissues. Previous studies demonstrated that estrogens suppress BMP functions by repressing BMP gene expression. Here we present a novel mechanism for the inhibi...
متن کاملCross-talk between estrogen and leptin signaling in the hypothalamus.
Obesity, characterized by enhanced food intake (hyperphagia) and reduced energy expenditure that results in the accumulation of body fat, is a major risk factor for various diseases, including diabetes, cardiovascular disease, and cancer. In the United States, more than half of adults are overweight, and this number continues to increase. The adipocyte-secreted hormone leptin and its downstream...
متن کاملCross talk between peptide growth factor and estrogen receptor signaling systems.
Epidermal growth factor reproduces many of the effects of estrogen on the murine female reproductive tract and may partially mediate estrogen-induced growth and differentiation. The mechanism by which the actions of estrogens and epidermal growth factor (EGF) converge is unknown. The studies described herein were performed to investigate the possibility that some of the actions of EGF may be me...
متن کاملCross-talk between bone morphogenetic proteins and inflammatory pathways
Pro-inflammatory cytokines and bone morphogenetic proteins are generally studied separately and considered to be elements of different worlds, immunology and developmental biology. Varas and colleagues report that these factors show cross-talk in rheumatoid arthritis synoviocytes. They show that pro-inflammatory cytokines not only stimulate the production of bone morphogenetic proteins but that...
متن کاملCross-talk between hypoxia and sphingolipid signaling
Hypoxia, e.g., inadequate supply of O2 with respect to needs, is a very common condition that invariantly leads to a variety of responses, which often result into relevant pathophysiological disorders. By sensing the lack of O2 and activating at the molecular level an array of strategies, cells and organisms can however compensate and/or adapt to hypoxia. Of the several mechanisms hitherto prop...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrinology
سال: 2002
ISSN: 0013-7227
DOI: 10.1210/en.143.7.2635